It seems the young Uzumaki was going to need some clear education on the situation. From his own words and the exact function of the plague jutsu, unless it was, "..allowed entry into a foreign body, whether it be through skin, or any orifice, the corrosive chakra infiltrates the chakra network.." etc, it wouldn't do as described. Considering the Uchiha had in fact expelled the Dokuton before, "the virus attacks eats away to his skin" and "as his armor fades".
Therefore, its clear to even a neophyte that the virus was ineffective in penetrating Madara in time, leaving the weather to clear and whatever remnants pushed beyond a mile if not destroyed. Though he didn't say exactly how much rain was in contact with him, he made it obvious it wasn't enough to overwhelm him considering also the lack of clarification on how fast this poison works, things weren't looking good for Ryoji as far as ending the battle, far from. In regards to the mention of how Madara's jutsu works, his opponent would do well to look up the definition of "variant". Perhaps actually utilize that extensive Uzumaki Library hes heard about? ;P Maybe it'll also help him know how the Uzumaki Sealing Technique actually works,
As the wiki says, 'After forming the necessary hand seals, the user slams their hand on the ground after which a sealing formula, that originates from the user's hand, forming underneath the target'. When the seal activates, anything above the inscription is sealed within the formula itself. "
Maybe this was forgivable if his opponent had used a different fuinjutsu, maybe perhaps..a variant? Even if it were possible, what would it do but seal a portion of his booticus? But lesson time is over, too bad Ryoji will soon be shaking hands with the Reaper to apply it. His opponent was right about one thing though, such taxation, even with infinite chakra, would bring about exhaustion even to Edo Tensei, however this would be circumvented. As his opponent sunk into the ground, Madara would take notice of his foe's sudden flux in chakra and then a disappearance of that signature entirely.
Activating the 7th Gate, Madara instantly becomes revitalized as well as gaining an extreme amount of speed and strength once Ryoji completely submerges into the ground, grabbing a marked kunai with one of his hands. The moment a part of him emerges, his chakra signature would return ("By overlapping their entire body, the user can completely conceal their presence and erase all traces of their chakra. This also allows the user to freely travel through the ground, enabling them to ambush opponents from below") as well as any negative intentions he had.
As the hand had poked him, Ryoji would find his (if it worked hypothetically..but it shouldn't since its "the" Uzumaki Sealing Technique) jutsu applied, but not in the place or person he intended. As he lunged, Madara used his incredible speed to shift to the right, most likely causing Ryoji to hit his side plate, where Zetsu resided, sealing him instead eventually. Regardless, immediately after Ryoji touches the Uchiha, he would utilize the Hiraishin Technique in order to re-position him (since he was in contact with him) face first into the fist that held the kunai.
Such a punch held behind it incredible power, capable of destroying an entire skeletal Susanoo. Such strength is further augmented by Demon Realm, which by itself holds behind it the physical raw might to crush the throat and rip the limbs off a user of Sage Mode. If somehow his head doesn't pop like a teenage zit, his strike should damage Ryoji's eyes and skull severely, most likely crushing his orbitals and fracturing the bones in his skull to puzzle pieces. The punch wouldn't stop there though, they would go off into a barrage of 20. The punches are so fast, they are set ablaze by sheer speed and friction which in turn creates a peacock-like fan of flames around the Ryoji if successful, obliterating the body.
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Flying Thunder God
Asura's Wrath (Morning Peacock Variant)