I was always told by the Shiki users of old, Sevilon, Mioku, Murcielago, Skinless....and I would love to see them or Court post here as they are the ones I have seen use it in the past...
That Kaguya's were disease resistant. Kimi had a blood disorder, not bacterial disease...And they were always searching for the cure. But you don't get infections cause of the natural resistance to disease.
Also...massive Bone creation takes some sort of calcium substitution/replacement pill. And the big bone forest move? It takes more than one turn to execute.
However, repairs to the skin are automatic. It happens while the cuts are being made, as is seen with any of Kimi's bone extractions. I would agree with the discussion thus far concerning organ damage though.
As I've mentioned to Kay here.. Yes. Kaguya's bodies are.. Well completely different from the norm. From how I took things eons ago til' now was a double edged sword. Your average cold/bacteria/virus isn't going to do anything to a Kaguya because of how different they are, (Notice how I didn't include poison) but at the same time your average healer isn't going to be able to heal/cure a Kaguya of something they may catch unless they were an expert on their physiology. Terrible example, but best I can think of right now as the difference between a vet and a regular doctor. Some similarities, but a doctor may not know how to cure a sickness that a bird or w/e may catch.
Other points that were mentioned were that.. The only tech/dance that really seemed to cause any exhaustion was the bone forest and unlike the other dance's it's classified as Kekkei Genkai/Ninjutsu instead of Taijutsu so take that as you will.
As for healing factor.. I always had the interpretation that due to the muscle, nerve, skin tear that your above average Kaguya would be able to heal damages to those specific areas to make up for the fact that no one else would be able to due to my previous point above with the 'alien physiology' as the Shikotsumyaku was/is supposed to be the 'ultimate' Taijutsu ability which is why Oro wanted it during his Uchiha predator phase. It would only make sense that an sturdy regenerating body would be something he wanted. I agree with organs.. If an organ is damaged.. The Shikotsumyaku ain't gonna help you.
On a lot of other points.. I generally agree with Kage since even before CS2 Kimi had big holes and such in his skin and body that were getting repaired and this is still while he wasn't at 100%