Well there's three more Hokage to take care of that. What's more, is that they're all Edo Tensei'd. But I wouldn't be surprised if Orochimaru decided to destroy the village with the former Hokage for some poetic vengeance.
But what I just noticed, was how the Uzumaki were in leaving around powerful artifacts in their destroyed homes. I guess they were eliminated for other good reasons, other than their fuinjutsu skills. This brings to question though, if the Dead Demon Consuming Seal is an Uzumaki technique? They had the means to summon Shinigami at any time, and release all the souls of any whom had been sealed, at the cost of a life of course.